1. Gantner ML*, Eade K*, Wallace M*, Handzlik MK, Fallon J, Trombley J, Bonelli R, Giles S, Harkins-Perry S, Heeren TFC, Sauer L, Ideguchi Y, Baldini M, Scheppke L, Dorrell MI, Kitano M, Hart BJ, Cai C, Nagasaki T, Badur MG, Okada M, Woods SM, Egan C, Gillies M, Guymer R, Eichler F, Bahlo M, Fruttiger M, Allikmets R, Bernstein P*, Metallo CM*, Friedlander M*. Serine and Lipid Metabolism in Macular Disease and Peripheral Neuropathy.NEJM (2019)
  2. Jung SM, Hung CM, Hildebrand SR, Sanchez-Gurmaches J, Martinez-Pastor B, Gengatharan JM, Wallace M, Mukhopadhyay D, Calejman CM, Luciano AK, Hsiao WY. Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1. Mol Cell 75(4):807-22 (2019)
  3. Wortham M, Liu F, Fleischman JY, Wallace M, Mulas F, Vinckier NK, Harrington AR, Cross BR, Chiou J, Patel NA, Sui Y. Nutrient regulation of the islet epigenome controls adaptive insulin secretion. bioRxiv 742403 (2019)
  4. Velez DO, Ranamukhaarachchi SK, Kumar A, Modi RN, Lim EW, Engler AJ, Metallo CM, Fraley SI. 3D collagen architecture regulates cell adhesion through degradability, thereby controlling metabolic and oxidative stress. Int Biol 11(5):221-34 (2019)
  5. Fernandez S, Viola JM, Torres A, Wallace M, Trefely S, Zhao S, Affronti HC, Gengatharan JM, Guertin DA, Snyder NW, Metallo CM. Adipocyte ACLY Facilitates Dietary Carbohydrate Handling to Maintain Metabolic Homeostasis in Females. Cell Rep 27(9):2772-84 (2019)
  6. Cordes T, Metallo CM. Quantifying Intermediary Metabolism and Lipogenesis in Cultured Mammalian Cells Using Stable Isotope Tracing and Mass Spectrometry. High-Throughput Metabolomics (pp. 219-241). Humana, New York, NY. (2019)
  7. Ramms B, Patel S, Nora C, Pessentheiner AR, Chang MW, Green CR, Golden GJ, Secrest P, Krauss RM, Metallo CM, Benner C. ApoC-III ASO Promotes Tissue LPL Activity in Absence of ApoE-Mediated TRL Clearance. J Lipid Res jlr-M093740 (2019)
  8. Reina-Campos M, Linares JF, Duran A, Cordes T, L’Hermitte A, Badur MG, Bhangoo MS, Thorson PK, Richards A, Rooslid T, Garcia-Olmo DC. Increased Serine and One-Carbon Pathway Metabolism by PKCl/i Deficiency Promotes Neuroendocrine Prostate Cancer. Cancer Cell 35:1-6 (2019)
  9. Garcia D, Hellberg K, Chaix A, Wallace M, Herzig S, Badur MG, Lin T, Shokhirev MN, Pinto AF, Ross DS, Saghatelian A. Genetic liver-specific AMPK activation protects against diet-induced obesity and NAFLD. Cell Rep 26(1):192-208 (2019)
  10. Badur MG, Muthusamy T, Parker SJ, Ma S, McBrayer SK, Cordes T, Magana JH, Guan KL, Metallo CM. Oncogenic R132 IDH1 mutations limit NADPH for de novo lipogenesis through (D) 2-Hydroxyglutarate production in fibrosarcoma cells. Cell Rep 25(4):1018 (2018)
  11. McBrayer SK, Mayers JR, DiNatale GJ, Shi DD, Khanal J, Chakraborty AA, Sarosiek KA, Briggs KJ, Robbins AK, Sewastianik T, Shareef SJ, Olenchock BA, Parker SJ, Tateishi K, Spinelli JB, Islam M, Haigis MC, Looper RE, Ligon KL, Bernstein BE, Carrasco RD, Cahill DP, Asara JM, Metallo CM, Yennawar NH, Vander Heiden MG, Kaelin WG. Transaminase inhibition by 2-hydroxyglutarate impairs glutamate biosynthesis and redox homeostasis in glioma. Cell 175(1):101-16. (2018)
  12. Wallace M, Green CR, Roberts LS, Lee YM, McCarville JL, Sanchez-Gurmaches J, Meurs N, Gengatharan JM, Hover JD, Phillips SA, Ciaraldi TP. Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues. Nat Chem Biol 14(11):1021 (2018)
  13. Wortham M, Benthuysen JR, Wallace M, Savas JN, Mulas F, Divakaruni AS, Liu F, Albert V, Taylor BL, Sui Y, Saez E. Integrated In Vivo Quantitative Proteomics and Nutrient Tracing Reveals Age-Related Metabolic Rewiring of Pancreatic β Cell Function. Cell Rep 25(10):2904-18 (2018)
  14. Sessions AO, Min P, Cordes T, Weickert BJ, Divakaruni AS, Murphy AN, Metallo CM, Engler AJ. Preserved cardiac function by vinculin enhances glucose oxidation and extends health-and life-span. APL Bioeng 2(3):036101. (2018)
  15. Skorobogatko Y, Dragan M, Cordon C, Reilly SM, Hung CW, Xia W, Zhao P, Wallace M, Lackey DE, Chen XW, Osborn O. RalA controls glucose homeostasis by regulating glucose uptake in brown fat. PNAS 115(30):7819-24. (2018)
  16. Zhao D, Badur MG, Luebeck J, Magaña JH, Birmingham A, Sasik R, Ahn CS, Ideker T, Metallo CM, Mali P. Combinatorial CRISPR-Cas9 metabolic screens reveal critical redox control points dependent on the KEAP1-NRF2 regulatory axis. Mol Cell 69(4):699-708 (2018)
  17. Sanchez-Gurmaches J, Tang Y, Jespersen NZ, Wallace M, Calejman CM, Gujja S, Li H, Edwards YJ, Wolfrum C, Metallo CM, Nielsen S. Brown fat AKT2 is a cold-induced kinase that stimulates ChREBP-mediated de novo lipogenesis to optimize fuel storage and thermogenesis. Cell Met 27(1):195-209 (2018)
  18. Jin L, Chun J, Pan C, Kumar A, Zhang G, Ha Y, Li D, Alesi GN, Kang Y, Zhou L, Yu WM. The PLAG1-GDH1 axis promotes anoikis resistance and tumor metastasis through CamKK2-AMPK signaling in LKB1-deficient lung cancer. Mol Cell 69(1):87-99 (2018)
  19. Badur MG, Metallo CM. Reverse engineering the cancer metabolic network using flux analysis to understand drivers of human disease. Met Eng 45:95-108 (2018)
  20. Linares JF, Cordes T, Duran A, Reina-Campos M, Valencia T, Ahn CS, Castilla EA, Moscat J, Metallo CM, Diaz-Meco MT. ATF4-induced metabolic reprograming is a synthetic vulnerability of the p62-deficient tumor stroma. Cell Met 26(6):817-29 (2017)
  21. Metallo CM, Deberardinis RJ. Engineering approaches to study cancer metabolism. Met Eng 43(Pt B):93 (2017)
  22. Divakaruni AS, Wallace M, Buren C, Martyniuk K, Andreyev AY, Li E, Fields JA, Cordes T, Reynolds IJ, Bloodgood BL, Raymond LA, Metallo CM, Murphy AN. Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death. J Cell Biol 216, 4 (2017)
  23. Zarei M, Lal S, Parker SJ, Nevler A, Vaziri-Gohar A, Dukleska K, Mambelli-Lisboa NC, Moffat C, Blanco FF, Chand SN, Jimbo M, Cozzitorto JA, Jiang W, Yeo CJ, Londin CJ, Londin E, Seifert EL, Metallo CM, Brody JR, Winter JM. Cancer Res (2017)
  24. Parker SJ, Svensson RU, Divakaruni AS, Lefebvre AE, Murphy AN, Shaw RJ & Metallo CM. LKB1 promotes metabolic flexibility in response to energy stress. Met Eng 2017
  25. Cordes T & Metallo CM. Tracing insights into human metabolism using chemical engineering approaches. Curr Opin Chem Eng 14 (2016)
  26. Huber AL, Papp SJ, Chan AB, Henriksson E, Jordan SD, Kriebs A, Nguyen M, Wallace M, Li Z, Metallo CM & Lamia KA. CRY2 and FBXL3 cooperatively degrade c-MYC. Mol Cell 64, 8 (2016)
  27. Zhao S, Torres A, Henry RA, Trefely S, Wallace M, Lee JV, Carrer A, Sengupta A, Campbell SL, Kuo Y-M, Frey AJ, Meurs N, Viola JM, Blair IA, Weljie AM, Metallo CM, Snyder NW, Andrews AJ & Wellen KE. ATP-citrate lyase controls a glucose-to-acetate metabolic switch. Cell Rep 17,4 (2016)
  28. Svensson RU, Parker SJ, Eichner LJ, Kolar MJ, Wallace M, Brun SN, Lombardo PS, Van Nostrand JL, Hutchins A, Vera L, Gerken L, Greenwood J, Bhat S, Harriman G, Westlin WF, Harwood HJ, Saghatelian A, Kapeller R, Metallo CM & Shaw RJ. Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models. Nat Med 22, 10 (2016)
  29. Zhang H, Badur MG, Divakaruni AS, Parker SJ, Jaeger C, Hiller K, Murphy AN & Metallo CM. Distinct metabolic states can support self-renewal and lipogenesis in human pluripotent stem cells under different culture conditions. Cell Rep 16, 1 (2015)
  30. Wallace M & Metallo CM. PGC1a drives a metabolic block on prostate cancer progession. Nat Cell Biol 18,6 (2016).
  31. Cordes T, Wallace M, Michelucci A, Divakaruni AS, Sapcariu SC, Sousa C, Koseki H, Cabrales P, Murphy AN, Hiller K & Metallo CM. Immunoresponsive gene 1 and itaconate inhibit succinate dehydrogenase to modulate intracellular succinate levels. J Biol Chem (2016)
  32. Parker SJ & Metallo CM. Chasing one-carbon units to understand role of serine in epigenetics. Mol Cell 61, 2 (2016)
  33. Green CR, Wallace M, Divakaruni AS, Phillips SA, Murphy AN, Ciaraldi TP & Metallo CM. Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis. Nat Chem Biol 12, 1 (2016)
  34. Lussey-Lepoutre C, Hollinshead KE, Ludwig C, Menara M, Morin A, Castro-Vega LJ, Parker SJ, Janin M, Martinelli C, Ottolenghi C, Metallo C, Gimenez-Roqueplo AP, Favier J, Tennant DA. Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism. Nat Commun (2015)
  35. Parker SJ & Metallo CM. Metabolic consequences of oncogenic IDH mutations. Pharm & Ther 152 (2015)
  36. Badur MG, Zhang H, Metallo CM. Enzymatic passaging of human embryonic stem cells alters central carbon metabolism and glycan abundance. Biotechnol J 10, 10 (2015)
  37. Parker SJ & Metallo CM. Metabolic consequences of oncogenic IDH mutations. Pharm & Ther 152 (2015)
  38. Ahn CS & Metallo CM. Mitochondria as biosynthetic factories for cancer proliferation. Cancer & Met 3, 1 (2015)
  39. Valencia T, Young Kim J, Abu-Baker S, Moscat-Pardos J, Ahn CS, Reina-Campos M, Duran A, Castilla EA, Metallo CM, Diaz-Meco JT & Moscat J. Metabolic reprogramming of stromal fibroblasts through p62-mTORC1 signaling promotes inflammation and tumorigenesis. Cancer Cell 26 (2014)
  40. Vacanti NM, Divakaruni AS, Green CR, Parker SJ, Henry RR, Ciaraldi TP, Murphy AN & Metallo CM. Regulation of substrate utilization by the mitochondrial pyruvate carrrier. Mol Cell 56, 3 (2014)
  41. Lewis CA, Parker SJ, Fiske BP, McCloskey D, Gui DY, Green CR, Vokes NI, Feist AM, Vander Heiden MG & Metallo CM. Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells. Mol Cell 55, 2 (2014)
  42. Grassian AR, Parker SJ, Davidson SM, Divakaruni AS, Green CR, Zhang X, Slocum, KL, Pu M, Lin F, Vickers C, Joud-Caldwell C, Chung F, Yin H, Handly ED, Straub C, Growney JD, Vander Heiden MG, Murphy AN, Pagliarini R & Metallo CM. IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism. Cancer Res 74, 3317 (2014)
  43. Heinrichsen ET, Zhang H, Robinson JE, Ngo J, Diop S, Bodmer R, Joiner WJ, Metallo CM, Haddad GG. Metabolic and transcriptional response to a high-fat diet in Drosophilia melanogaster. Mol Metab 3, 1 (2014)
  44. C. Commisso, S. M. Davidson, R. G. Soydaner-Azeloglu, S. J. Parker, J. J. Kamphorst, S. Hackett, E. Grabocka, M. Nofal, J. A. Drebin, C. B. Thompson, J. D. Rabinowitz, C. M. Metallo, M. G. Vander Heiden, D. Bar-Sagi. Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature 497, 633 (2013)
  45. K. Hiller, C. M. Metallo. Profiling metabolic networks to study cancer metabolism. Curr Opin Biotechnol 24, 60 (2013)
  46. K. Hiller, A. Wegner, D. Weindl, T. Cordes, C. M. Metallo, J. K. Kelleher, G. Stephanopoulos. NTFD--a stand-alone application for the non-targeted detection of stable isotope-labeled compounds in GC/MS data. Bioinformatics 29, 1226 (2013)
  47. C. M. Metallo, M. G. Vander Heiden. Understanding metabolic regulation and its influence on cell physiology. Mol Cell 49, 388 (2013)
  48. D. Anastasiou, Y. Yu, W. J. Israelsen, J. K. Jiang, M. B. Boxer, B. S. Hong, W. Tempel, S. Dimov, M. Shen, A. Jha, H. Yang, K. R. Mattaini, C. M. Metallo, B. P. Fiske, K. D. Courtney, S. Malstrom, T. M. Khan, C. Kung, A. P. Skoumbourdis, H. Veith, N. Southall, M. J. Walsh, K. R. Brimacombe, W. Leister, S. Y. Lunt, Z. R. Johnson, K. E. Yen, K. Kunii, S. M. Davidson, H. R. Christofk, C. P. Austin, J. Inglese, M. H. Harris, J. M. Asara, G. Stephanopoulos, F. G. Salituro, S. Jin, L. Dang, D. S. Auld, H. W. Park, L. C. Cantley, C. J. Thomas, M. G. Vander Heiden. Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nat Chem Biol 8, 1008 (2012)
  49. C. M. Metallo. Expanding the reach of cancer metabolomics. Cancer Prev Res (Phila) 5, 1337 (2012)
  50. C. M. Metallo, P. A. Gameiro, E. L. Bell, K. R. Mattaini, J. Yang, K. Hiller, C. M. Jewell, Z. R. Johnson, D. J. Irvine, L. Guarente, J. K. Kelleher, M. G. Vander Heiden, O. Iliopoulos, G. Stephanopoulos. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature 481, 380 (2012)
  51. N. M. Vacanti, C. M. Metallo. Exploring metabolic pathways that contribute to the stem cell phenotype. Biochim Biophys Acta, (2012)
  52. J. L. Walther, C. M. Metallo, J. Zhang, G. Stephanopoulos. Optimization of 13C isotopic tracers for metabolic flux analysis in mammalian cells. Metab Eng 14, 162 (2012)
  53. D. Gaglio, C. M. Metallo, P. A. Gameiro, K. Hiller, L. S. Danna, C. Balestrieri, L. Alberghina, G. Stephanopoulos, F. Chiaradonna. Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth. Mol Syst Biol 7, 523 (2011)
  54. A. R. Grassian, C. M. Metallo, J. L. Coloff, G. Stephanopoulos, J. S. Brugge. Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation. Genes Dev 25, 1716 (2011)
  55. K. Hiller, C. Metallo, G. Stephanopoulos. Elucidation of cellular metabolism via metabolomics and stable-isotope assisted metabolomics. Curr Pharm Biotechnol 12, 1075 (2011)
  56. J. W. Locasale, A. R. Grassian, T. Melman, C. A. Lyssiotis, K. R. Mattaini, A. J. Bass, G. Heffron, C. M. Metallo, T. Muranen, H. Sharfi, A. T. Sasaki, D. Anastasiou, E. Mullarky, N. I. Vokes, M. Sasaki, R. Beroukhim, G. Stephanopoulos, A. H. Ligon, M. Meyerson, A. L. Richardson, L. Chin, G. Wagner, J. M. Asara, J. S. Brugge, L. C. Cantley, M. G. Vander Heiden. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat Genet 43, 869 (2011)
  57. M. G. Vander Heiden, S. Y. Lunt, T. L. Dayton, B. P. Fiske, W. J. Israelsen, K. R. Mattaini, N. I. Vokes, G. Stephanopoulos, L. C. Cantley, C. M. Metallo, J. W. Locasale. Metabolic pathway alterations that support cell proliferation. Cold Spring Harb Symp Quant Biol 76, 325 (2011)
  58. K. Hiller, C. M. Metallo, J. K. Kelleher, G. Stephanopoulos. Nontargeted elucidation of metabolic pathways using stable-isotope tracers and mass spectrometry. Anal Chem 82, 6621 (2010)
  59. C. M. Metallo, S. M. Azarin, L. E. Moses, L. Ji, J. J. de Pablo, S. P. Palecek. Human embryonic stem cell-derived keratinocytes exhibit an epidermal transcription program and undergo epithelial morphogenesis in engineered tissue constructs. Tissue Eng Part A 16, 213 (2010)
  60. C. M. Metallo, L. Ji, J. J. de Pablo, S. P. Palecek. Directed differentiation of human embryonic stem cells to epidermal progenitors. Methods Mol Biol 585, 83 (2010)
  61. C. M. Metallo, M. G. Vander Heiden. Metabolism strikes back: metabolic flux regulates cell signaling. Genes Dev 24, 2717 (2010)
  62. C. M. Metallo, J. L. Walther, G. Stephanopoulos. Evaluation of 13C isotopic tracers for metabolic flux analysis in mammalian cells. J Biotechnol 144, 167 (2009)
  63. C. M. Metallo, S. M. Azarin, L. Ji, J. J. de Pablo, S. P. Palecek. Engineering tissue from human embryonic stem cells. J Cell Mol Med 12, 709 (2008)
  64. C. M. Metallo, L. Ji, J. J. de Pablo, S. P. Palecek. Retinoic acid and bone morphogenetic protein signaling synergize to efficiently direct epithelial differentiation of human embryonic stem cells. Stem Cells 26, 372 (2008)
  65. C. M. Metallo, M. A. Vodyanik, J. J. de Pablo, Slukvin, II, S. P. Palecek. The response of human embryonic stem cell-derived endothelial cells to shear stress. Biotechnol Bioeng 100, 830 (2008)
  66. C. M. Metallo, J. C. Mohr, C. J. Detzel, J. J. de Pablo, B. J. Van Wie, S. P. Palecek. Engineering the stem cell microenvironment. Biotechnol Prog 23, 18 (2007)
  67. L. Xie, C. Metallo, J. Warren, W. Pilbrough, J. Peltier, T. Zhong, L. Pikus, A. Yancy, J. Leung, J. G. Aunins, W. Zhou. Large-scale propagation of a replication-defective adenovirus vector in stirred-tank bioreactor PER.C6 cell culture under sparging conditions. Biotechnol Bioeng 83, 45 (2003)
  68. L. Xie, W. Pilbrough, C. Metallo, T. Zhong, L. Pikus, J. Leung, J. G. Aunins, W. Zhou. Serum-free suspension cultivation of PER.C6(R) cells and recombinant adenovirus production under different pH conditions. Biotechnol Bioeng 80, 569 (2002)